RAAS Inhibition Provides Improvement in 1 Year Mortality Post LVAD Implantation
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چکیده
منابع مشابه
RAAS inhibition and mortality in hypertension
The renin-angiotensin-aldosterone system (RAAS) regulates the body's hemodynamic equilibrium, circulating volume, and electrolyte balance, and is a key therapeutic target in hypertension, the world's leading cause of premature mortality. Hypertensive disorders are strongly linked with an overactive RAAS, and RAAS inhibitors, like angiotensin-converting enzyme (ACE) inhibitors and angiotensin re...
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Left ventricular remodeling after myocardial infarction has been identified as a predictor of adverse outcome and as a relevant therapeutic target. It has been shown that upregulation of the renin– angiotensin–aldosterone system (RAAS) has an important role in the pathogenesis of cardiac remodeling. In this paper we summarize evidence on the role of the RAAS in the development of left ventricul...
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PHARMACOLOGICAL EVIDENCE FOR RAAS INHIBITION ACE inhibitors and ARBs inhibit the RAAS in distinct ways. ACE inhibitors prevent the enzyme ACE from converting angiotensin I into angiotensin II (Table 1) [7, 8]. Angiotensin II is a vasoconstrictor that causes a host of deleterious effects, including vascular damage at the endothelial and structural levels [9]. Angiotensin II is an important cause...
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Angiotensin II type 1 receptor blocker (ARB), which is frequently prescribed in patients with glomerulonephritis (GN), is suggested to increase the risk of cancer. We registered 3,288 patients with renal biopsy and analyzed the relationship between the use of renin-angiotensin-aldosterone system (RAAS) blockade and the incidence of cancer or cancer mortality. After renal biopsy, cancer develope...
متن کاملImmediate post-LVAD implant support: two approaches.
Increased use of left ventricular assist devices (LVAD) as bridges to transplant has revealed the need for short-term right heart support for deairing and right ventricular recovery. The two approaches described are implemented as the patient is weaned from regular cardiopulmonary bypass. Dependent on patient needs, the surgeon may select a high-flow or low-flow approach to what is essentially ...
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ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2021
ISSN: 1053-2498
DOI: 10.1016/j.healun.2021.01.1244